Journal
CURRENT STEM CELL RESEARCH & THERAPY
Volume 14, Issue 5, Pages 428-436Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X13666181002151330
Keywords
Cancer stem cells; tumor microenvironment; integrin alpha 6; laminins; self-renewal; cell signalling
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Funding
- NIH [R15CA182889-01]
- Center of Biomedical Research at Oakland University
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Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin alpha 6 (ITGA6, also blown as CD49f) in Cancer Stem Cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.
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