Journal
CELL REPORTS
Volume 26, Issue 2, Pages 394-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.12.044
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Funding
- NIH NINDS, United States [R01 NS074039]
- Swiss National Science Foundation, Switzerland [31003A_163088]
- University of Basel, Switzerland
- NIH/NIBIB, United States [K01EB016071]
- NIH/NCI, United States [R33CA202827]
- NRSA Ruth Kirschstein Postdoctoral Fellowship, United States [NIH NINDS F32 NS090736]
- Swiss National Science Foundation (SNF) [31003A_163088] Funding Source: Swiss National Science Foundation (SNF)
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The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural stem cells exhibit features of astrocytes, have a regional identity, and depending on their location in the lateral or septal wall of the lateral ventricle, generate different types of neuronal and glial progeny. We performed large-scale single-cell RNA sequencing to provide a molecular atlas of cells from the lateral and septal adult V-SVZ of male and female mice. This revealed regional and sex differences among adult V-SVZ cells. We uncovered lineage potency bias at the single-cell level among lateral and septal wall astrocytes toward neurogenesis and oligodendrogenesis, respectively. Finally, we identified transcription factor co-expression modules marking key temporal steps in neurogenic and oligodendrocyte lineage progression. Our data suggest functionally important spatial diversity in neurogenesis and oligodendrogenesis in the adult brain and reveal molecular correlates of adult NSC dormancy and lineage specialization.
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