Journal
ADVANCED HEALTHCARE MATERIALS
Volume 8, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201800995
Keywords
photoacoustic imaging; photothermal therapy; supracarbon nanodots
Funding
- National Natural Science Foundation of China [51602304]
- Youth Innovation Promotion Association of CAS
- Jilin Province Science and Technology Research Projects [20170101191JC, 20170101042JC, 20160520008JH, 20150519003JH, 20160101157JC]
- 13th Five-Year Plan for Education Department of Jilin Province [JJKH20180232KJ]
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Carbon nanodots (CNDs) with high photothermal conversion efficiency are considered as emerging nanomaterials for advanced biomedical applications attributing to their high biocompatibility, low-cost, and unique photophysical properties. In previous work, supra-CNDs are synthesized exhibiting high absorption in the near-infrared (NIR) region and good NIR photothermal conversion performance. In this work, supra-CNDs are explored as a photothermal agent for photothermal therapy (PTT) and a contrast agent for photoacoustic (PA) imaging, respectively. As a result, in vivo tumor PTT is realized under 655 nm laser irradiation via intratumor injecting supra-CNDs. In vivo PA imaging reveals that supra-CNDs can accumulate in the tumor tissue via the blood circulation after intravenous injection. Moreover, in vivo PTT is conducted after intravenous injection and subsequent tumor accumulation of supra-CNDs, and the lives of mice are prolonged due to the tumor growth inhibition after PTT. These attractive properties indicate that the supra-CNDs can be used as biomedical agents for PA imaging and tumor therapy.
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