Journal
ACTA OTO-LARYNGOLOGICA
Volume 136, Issue 8, Pages 759-763Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00016489.2016.1160423
Keywords
Inflammatory cytokines; intensity-modulated radiotherapy; nasopharyngeal carcinoma; VEMP; vestibular function disorders
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Funding
- Clinical Medicine Science and Technology Innovation Project of Jinan City [201506005]
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Conclusions: Vestibular function disorders were widespread among nasopharyngeal carcinoma (NPC) patients. The radiation doses to the inner ears were associated with the incidence of vestibular function disorders, but the correlations were mild. The inflammatory responses and possible resolution obstacles of inflammation participated in persistent vestibular function disorders after irradiation. Objectives: To investigate the incidence of vestibular function disorders in NPC patients after irradiation and potential mechanisms. Methods: Patients who received radical intensity-modulated radiotherapy for their NPC were recruited. The serum levels of IL-6 and IL-17 were detected by ELISA method. Vestibular evoked myogenic potential (VEMP) tests were used to evaluate vestibular function and correlation analyses were used to analyze the potential mechanisms of vestibular function disorders. Results: Thirty-eight patients were included. The incidences of abnormal ocular VEMP (oVEMP) and cervical VEMP (cVEMP) were 65.79% and 80.26% at the time of completion of radiotherapy, and 61.84% and 71.05% at 3 months after radiotherapy. The mean and maximum radiation doses to the inner ears were both significantly associated with abnormal oVEMP and cVEMP (p<0.05, all), but the correlations were all mild. The serum levels of IL-6 and IL-17 were both significantly associated with abnormal oVEMP and cVEMP after irradiation (p<0.05, all).
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