Journal
NUTRIENTS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nu10111691
Keywords
aging; muscle; protein; metabolism; metabolomics; profiling; biomarkers; multi-marker; physical performance; multivariate
Categories
Funding
- Fondazione Roma
- Innovative Medicines Initiative-Joint Undertaking [IMI-JU 115621]
- nonprofit research foundation Centro Studi Achille e Linda Lorenzon
- Universita Cattolica del Sacro Cuore [D3.2 2013, D3.2 2015]
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Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/ amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares-Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 +/- 3.9% (75.1 +/- 4.6% for enrollees with PF & S; 78.5 +/- 6.0% for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF& S participants was defined by higher concentrations of ff alpha-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.
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