Journal
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
Volume 12, Issue 11, Pages 996-1001Publisher
J INFECTION DEVELOPING COUNTRIES
DOI: 10.3855/jidc.10988
Keywords
Antimicrobials; biopharmaceuticals; hip implants; infection; Pseudomonas spp.
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Introduction: Essential oils have been used since ancient times and are known for their anti-inflammmatory, anti-depressive, antiseptic, antifungal and antimicrobial properties. Methodology: in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris-red thyme geraniol was tested against 16 multidrug-resistant P. aeruginosa strains from infected hip implants as well as the in vitro cytotoxic activity on normal human Wong-Kilbourne derivative (WKD) cells. Results: Thymus vulgaris-red thyme geraniol showed lower antimicrobial activity when compared to Melaleuca alternifolia. All tested oils were cytotoxic at concentrations lower than 0.12%. Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural treatments together with higher concern on environmental issues and natural lifestyle.
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