Journal
BIOMEDICAL OPTICS EXPRESS
Volume 9, Issue 12, Pages 6009-6016Publisher
Optica Publishing Group
DOI: 10.1364/BOE.9.006009
Keywords
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Funding
- National Institute of General Medical Sciences
- National Institute of Dental and Craniofacial Research of the National Institute of Health [SC2DE027240]
- National Science Foundation [1332444]
- Division Of Human Resource Development
- Direct For Education and Human Resources [1332444] Funding Source: National Science Foundation
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Early detection of dental caries is critical for avoiding more invasive and advanced treatment at a later stage. However. currently available techniques are unsatisfactory for early detection. Raman spectroscopy is known to have both high sensitivity and specificity in the analysis of mineral content in a tooth: but translating Raman spectroscopy to clinical caries detection remains a challenge. In this study. we report a full-scale Raman imaging system that can provide fast full-scale (similar to 7 mm in diameter) tooth mineral analysis which could be feasible for clinical application. The results show that the Raman imaging system could not only confirm carious lesions that are obvious to the naked eye but also identify those which are not conclusive to traditional visual examination and probing. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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