Journal
ACS COMBINATORIAL SCIENCE
Volume 21, Issue 2, Pages 35-68Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.8b00172
Keywords
solid-phase synthesis; pyrimidine derivatives; microwave irradiation
Funding
- University Grants Commission, India
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This Review describes the existing synthetic approaches for the solid-phase synthesis (SPS) of differently substituted and fused pyrimidine derivatives. These synthetic strategies are classified on the basis of the different synthetic routes leading to the particular type of pyrimidine heterocycle formed. The Review discusses the application of a variety of polystyrene derived supports for the construction of pyrimidine rings. The effect of microwave heating on the solid-phasesynthesis is also addressed in the review.
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