Journal
ACS CATALYSIS
Volume 8, Issue 12, Pages 11847-11853Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b04079
Keywords
photoredox catalysis; Minisci reaction; C-H functionalization; hypervalent iodine; heteroarene
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Funding
- Natural Science Foundation of China [21672105, 21725204, 91753124]
- Natural Science Foundation of Tianjin [18JCZDJC32800]
- Laviana
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We report a highly efficient and chemoselective Minisci-type alkylation reaction of N-heteroarenes with alkanes under the reagent control of a hypervalent iodine oxidant PFBI-OH. In addition to the high reactivity, PFBI-OH demonstrated a high steric sensitivity for H abstraction of alkanes. This reaction is selective for more sterically accessible secondary C-H bonds over weaker tertiary C-H bonds. High selectivity toward penultimate methylene groups was observed for a wide range of acyclic alkanes.
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