Journal
ACS CATALYSIS
Volume 9, Issue 1, Pages 775-780Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b04348
Keywords
gem-difluoroalkenes; C-F bond Cleavage; C-O bond cleavage; reductive cross-coupling; acetals
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Funding
- 1000-Youth Talents Plan starting up funding
- National Natural Science Foundation of China [21772183]
- Fundamental Research Funds for the Central Universities [WK2060190086]
- University of Science and Technology of China
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By merging C-O and C-F bond cleavage in cross-electrophile coupling, we developed a method for efficient synthesis of gem-difluoroalkenes with an alkoxy-substituent on the homoallylic position using easily accessible acetals as coupling partners with alpha-trifluoromethyl alkenes. Remarkably, this Ni-catalyzed allylic defluorinative cross-coupling reaction demonstrates high tolerance of a wide range of sensitive functional groups and proves to be applicable in late-stage functionalization of structurally complex compounds.
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