Journal
ACS CATALYSIS
Volume 9, Issue 1, Pages 236-241Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b04191
Keywords
dicarbofunctionalization; deamination; redox-active; photoredox catalysis; visible-light
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Funding
- Fonds der Chemischen Industrie
- Alexander von Humboldt Foundation
- University of Toronto
- J.J. Berry Smith Award
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The visible-light-mediated three-component dicarbofunctionalization of styrenes using simple benzylic radicals is described. Notably, this work describes a rare example of undirected dicarbofunctionalization using unsubstituted benzyl radicals. Key to the success of this strategy was the rational design and use of benzylic pyridinium salts as radical precursors. Using this approach, abundant styrenes, electron-rich heterocycles, and benzylic amines were combined to rapidly afford a number of densely functionalized 1,1-diarylalkanes. A dipeptide-derived pyridinium salt was applied in this transformation, which resembles a visible-light-mediated deaminative generation of radicals from peptides.
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