Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-018-07748-z
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Funding
- Leverhulme Trust [F/07134/DF]
- BBSRC [BB/I021213/1]
- Excellence Initiative of Aix-Marseille University-A*MIDEX (a French Investissements d'Avenir programme)
- Wellcome Trust/Royal Society [098386/Z/12/Z]
- Universidad de Antioquia (CODI sostenibilidad de grupos 2013-2014)
- Universidad de Antioquia (MASO 2013-2014)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (Apoio a Nucleos de Excelencia Program)
- Fundacao de Aperfeicoamento de Pessoal de Nivel Superior
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BPD/76207/2011]
- Programa Operacional Potencial Humano (POCH) [SFRH/BPD/76207/2011]
- FCT
- Wellcome Trust [098051]
- UCL Global Engagement Fund
- Wellcome Investigator Award [WT107055AIA]
- COLCIENCIAS (Colombia)
- BBSRC [BB/I021213/1] Funding Source: UKRI
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/76207/2011] Funding Source: FCT
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Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.
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