Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-07053-9
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Funding
- MS Research grant [MS13-832]
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Most tissues are populated by tissue-resident memory T cells (T-RM cells), which are adapted to their niche and appear to be indispensable for local protection against pathogens. Here we show that human white matter-derived brain CD8(+) T cells can be subsetted into CD103(-)CD69(+) and CD103(+)CD69(+) T cells both with a phenotypic and transcription factor profile consistent with T-RM cells. Specifically, CD103 expression in brain CD8(+) T cells correlates with reduced expression of differentiation markers, increased expression of tissue-homing chemokine receptors, intermediate and low expression of the transcription factors T-bet and eomes, increased expression of PD-1 and CTLA-4, and low expression of cytolytic enzymes with preserved polyfunctionality upon activation. Brain CD4(+) T cells also display T-RM cell-associated markers but have low CD103 expression. We conclude that the human brain is surveilled by T-RM cells, providing protection against neurotropic virus reactivation, whilst being under tight control of key immune checkpoint molecules.
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