Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-018-06918-3
Keywords
-
Categories
Funding
- Wellcome Trust [200841/Z/16/Z]
- Cambridge NIHR BRC Cell Phenotyping Hub
- Associazione Italiana Ricerca per la Ricerca sul Cancro (AIRC)-Special Project 5x1000 [9962]
- AIRC IG 2017 [19920]
- AIRC [15283]
- Ministero della Salute RF-2013 [GR-2013-02356568]
- CTR PhD fellowship
- Centre for Trophoblast Research (CTR)
- MRC [MR/P001092/1] Funding Source: UKRI
Ask authors/readers for more resources
Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes(+)CD49a(+) NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with TGF-beta responses and interactions with trophoblast, epithelial, endothelial, smooth muscle cells, leucocytes and extracellular matrix. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-gamma. Eomes(-)CD49a(+) ILC1s dominate before puberty, and specifically expand in second pregnancies when the expression of the memory cell marker CXCR6 is upregulated. These results identify trNK cells as the cellular hub of uterine group 1 ILCs, and mark CXCR6(+) ILC1s as potential memory cells of pregnancy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available