Journal
EPIGENOMICS
Volume 10, Issue 11, Pages 1499-1509Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2017-0151
Keywords
cancer; drug resistance; exosomes; miRNA
Categories
Funding
- National Key Research and Development Program of China [2016YFC0905900]
- Natural Science Foundation of Jiangsu Province [BK20151579]
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Exosomes are smallmembrane vesicles with a diameter of 40-100 nm, which are released into the intracellular environment. Exosomes could influence the genetic and epigenetic changes of receptor cells by promoting the horizontal transfer of various proteins or RNAs, especially miRNAs. Moreover, exosomes also play an important role in tumor microenvironment. Exosomes could promote the short-and long-distance exchanges of genetic information by acting as mediators of cell-to-cell communication. In addition, exosomes participate in drug resistance of tumor cells by genetic exchange between cells. It is reported that exosomes could be absorbed by recipient cells and transmit chemoresistance from drug-resistant tumor cells to sensitive ones. Then understanding the mechanisms of chemotherapy failure and controlling tumor progression effectively will be amajor challenge for us. Therefore, in this review, we will briefly reveal the role of exosomes in drug resistance.
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