Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 2, Pages 175-179Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.8b00473
Keywords
Portimine; spiroimine; Vulcanodinium rugosum; dinoflagellate; apoptosis; OCSSC; natural products
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Funding
- Children's Hospital of Michigan Foundation
- Department of Pediatrics at the Wayne State University School of Medicine
- Department of Otolaryngology at the Wayne State University School of Medicine
- Marbionc Program at UNC Wilmington
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Spiroimines are a class of compounds produced by marine dinoflagellates with a wide range of toxicity and therapeutic potential. The smallest of the cyclic imines, portimine, is far less toxic than other known members in several animal models. Portimine has also been shown to induce apoptosis and reduce the growth of a variety of cancer cell lines at low nanomolar concentrations. In an effort to discover new spiroimines, the current study undertook a metabolomic analysis of cultures of cyclic imine-producing dinoflagellates, and a new analog of portimine was discovered in which the five-membered cyclic ether is open. Further scrutiny with human oral cavity squamous cell carcinoma (OCSCC) cell lines revealed that the open ring congener was less potent than portimine A but could still lead to the accumulation of apoptotic gene transcripts, fragment genomic DNA, and reduce cancer cell proliferation in the range of 100-200 nM.
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