Journal
BMC OPHTHALMOLOGY
Volume 18, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12886-018-1011-z
Keywords
Diabetic mellitus; Diabetic retinopathy; Ultra-wide-field retinal imaging systems; Early treatment of diabetic retinopathy study diabetic retinopathy severity; International clinical diabetic retinopathy severity
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BackgroundThe ability to image wide fundus fields and to conduct swift, non-invasive examinations is increasingly important with the escalation in patients with diabetic retinopathy (DR).MethodsFifty eyes of 28 consecutive patients with DR were examined in this prospective observational study. A total of 46 eyes, 25 right and 21 left eyes, of 27 patients (male, 19; female, 8) were ultimately included in the analysis. All patients underwent comprehensive ophthalmological examination. A single image each was obtained using two ultra-wide-field (UWF) imaging systems: Optos (R) (Optos Carfornia (R), Optos PLC, Dunfermline, United Kingdom) and Clarus (CLARUS 500, Carl Zeiss Meditec Inc., Californea, USA), without mydriasis. The total retinal area captured and the obscured retinal area were compared between the two systems using nonparametric Wilcoxon matched-pairs signed-rank analysis. Early Treatment of Diabetic Retinopathy Study (ETDRS) and International Clinical DR severity were analyzed by statistics.ResultsThe Optos (R) allowed capture of larger areas of the fundus than the Clarus (465117 vs. 243 +/- 39 disc areas, P<0.0001). In 85% (39/46) of Optos (R) images and 7% (3/46) of Clarus images, a slightly obscured area was observed within the ETDRS-7 field area. values for ETDRS DR severity and International Clinical DR severity between the Optos (R) and Clarus images were 0.88 and 0.79, respectively. Severity was higher according to Clarus images in two eyes in which the ETDRS DR severity grading differed between the systems. Severity was higher in four Clarus images and in a single Optos (R) image in five eyes in which the International Clinical DR severity grading differed between the systems.Conclusion The Optos (R) and Clarus UWF retinal imaging systems were useful for examining eyes with DR, using single images obtained without mydriasis. The systems were both generally consistent in assessing DR severity, with some partial discrepancies. It is important to understand the characteristics of each respective UWF retinal imaging system when using them to assess DR.
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