Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 12, Issue 3, Pages 211-220Publisher
SPRINGER
DOI: 10.1007/s12265-018-9849-2
Keywords
Atherosclerosis; Intravascular imaging; Photoacoustic imaging; Near-infrared spectroscopy; Lipid core plaque; Perivascular adipose tissue; Swine; Human
Funding
- Center of Excellence in Cardiovascular Research Grant
- Fortune-Fry Ultrasound Research Fund
- American Heart Association Postdoctoral Fellowship [16POST27480018]
- Edna M. Donnan Fellowship
- [R01HL125385]
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Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology. Both modalities showed significantly greater lipid in MetS vs. lean swine, but only IVPA-US localized the lipid as perivascular. To investigate late-stage atherosclerosis, we performed ex vivo IVPA-US imaging of a human coronary artery with comparison to NIRS-IVUS and histology. Two advanced fibroatheromas were identified, with agreement between IVPA-measured lipid area and NIRS-derived lipid content. As confirmed histologically, IVPA-US has sensitivity to detect lipid content similar to NIRS-IVUS and provides additional depth resolution, enabling quantification and localization of lipid cores within plaques.
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