Related references
Note: Only part of the references are listed.Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
Jayme L. Dahlin et al.
NATURE COMMUNICATIONS (2017)
Dynamic cytotoxic profiles of sulfur mustard in human dermal cells determined by multiparametric high-content analysis
Long Long et al.
TOXICOLOGY RESEARCH (2016)
Sirtuin inhibitor sirtinol is an intracellular iron chelator
R. Gautam et al.
CHEMICAL COMMUNICATIONS (2015)
Tackling reproducibility in academic preclinical drug discovery
Stephen V. Frye et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts
Fangyang Wang et al.
MOLECULAR ONCOLOGY (2014)
Chemical con artists foil drug discovery
Jonathan Baell et al.
NATURE (2014)
Novel PPAR Pan Agonist, ZBH Ameliorates Hyperlipidemia and Insulin Resistance in High Fat Diet Induced Hyperlipidemic Hamster
Wei Chen et al.
PLOS ONE (2014)
Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: Comparison with TPEN and PAC-1
O. Alexander H. Astrand et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
Joanne Bowes et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)
Danny C. Hsu et al.
ACS COMBINATORIAL SCIENCE (2012)
Development of a Plate-Based Assay for High-Content Analysis of Individual Untethered Non-Adherent Cells
Chen Wang et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2011)
Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors
Yan Qin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Lunasin peptide purified from Solanum nigrum L. protects DNA from oxidative damage by suppressing the generation of hydroxyl radical via blocking fenton reaction
Jin Boo Jeong et al.
CANCER LETTERS (2010)
Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound
Quinn P. Peterson et al.
CANCER RESEARCH (2010)
Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo
Jieru Meng et al.
PLOS ONE (2010)
Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism
Kristina M. Cook et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Procaspase-3 Activation as an Anti-Cancer Strategy: Structure-Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3
Quinn P. Peterson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition
Quinn P. Peterson et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Small-Molecule Activators of a Proenzyme
Dennis W. Wolan et al.
SCIENCE (2009)
Small molecules not direct activators of caspases
Jean-Bernard Denault et al.
NATURE CHEMICAL BIOLOGY (2007)
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
Karson S. Putt et al.
NATURE CHEMICAL BIOLOGY (2006)
A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation
Louise K. Charkoudian et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Ribonucleotide reductase inhibitors and future drug design
J. Shao et al.
CURRENT CANCER DRUG TARGETS (2006)
The zinc chelator, N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1α protein in normoxic cells
SM Choi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid
LK Charkoudian et al.
INORGANIC CHEMISTRY (2006)
Suppression of hypoxia-inducible factor 1α (HIF-1α) transcriptional activity by the HIF prolyl hydroxylase EGLN1
KKW To et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
LA McNeill et al.
MOLECULAR BIOSYSTEMS (2005)
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
N Masson et al.
JOURNAL OF CELL SCIENCE (2003)
Share Paper
