Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 50, Issue -, Pages 192-200Publisher
ELSEVIER
DOI: 10.1016/j.jff.2018.09.033
Keywords
Curcumin; Chemoprevention; Diarylpentanoid analog; Gastric cancer; Pyrolysis; STAT3 inhibition
Categories
Funding
- Akita Industrial/Academic/Governmental Research Project on Developing Innovations, Joint Research and Promotion Project on Creating New Technologies and Industries
- Yamasaki Spice Promotion Foundation
- JSPS KAKENHI [JP 16H06276]
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Gastric cancer is the second leading cause of cancer-related mortality worldwide. Curcumin, a phytochemical, possesses molecular inhibitory potentials for regulating malignancies. However, the lower potential of curcumin warrants improvement. Thus, we synthesized diarylpentanoid analogs with higher potency; however, these differed structurally from curcumin-a heptanoid. Recently, one diarylpentanoid was formed following pyrolysis of curcumin, which is identical to our GO-Y022. The growth inhibition of gastric cancer cells by GO-Y022 was five-fold higher than by curcumin; GO-Y022 displayed superior apoptosis induction ability. Besides, it suppressed the gastric tumor growth to a third in a mouse model. GO-Y022 was moved to the epithelial and gastric tumors but not detected in the bloodstream. Moreover, oral GO-Y022 was effective topically, exhibited no adverse events in mice, and was detected in the commercially available curry paste. Briefly, GO-Y022 can inhibit gastric carcinogenesis; it is dietary and can be safely used as an oral functional food.
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