Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 52, Issue -, Pages 492-504Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.11.018
Keywords
A-type EGCG dimer; Inhibition; A beta(40); Amyloid fibril
Categories
Funding
- National Natural Science Foundation of China [31571839]
- Fundamental Research Funds for the Central Universities [2662016QD035]
Ask authors/readers for more resources
A-type EGCG dimer is a new proanthocyanidins dimer from persimmon fruits. In the present study, we firstly examined the effects of EGCG and A-type EGCG dimer on A beta(40)-fibrillization, and then the detailed mechanisms behind the inhibitory effects of polyphenols on A beta(40) amyloid fibrils formation were investigated by PICUP assay, ESI-MS, NMR and molecular docking. Our results confirmed that A-type EGCG dimer exhibited stronger inhibitory effect on the formation of A beta(40) amyloid fibrils. We found that A-type EGCG dimer possessed more binding sites on A beta(40) peptide than EGCG. Notably, compared with EGCG, A-type EGCG dimer could interact with more amino acid residues which possessed obvious aggregation-propensity. And our results also suggested that the hydrophobic interaction was the principal driving force to inhibit the formation of A beta(40) amyloid fibrils by A-type EGCG dimer. We believed that our study could provide useful insights for the design of low-molecular weight inhibitors of A beta aggregation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available