Kiwifruit seed oil ameliorates inflammation and hepatic fat metabolism in high-fat diet-induced obese mice

The aim of this study is to investigate the effect of kiwifruit seed oil (KSO) on inflammation and hepatic fat metabolism in high-fat diet (HFD)-induced C57BL/6 obese mice for 12 consecutive weeks by oral intervention. The results showed that KSO supplementation inhibited the body weight gain, decreased fasting blood glucose and insulin levels, and alleviated glucose and insulin tolerance in obese mice. KSO supplementation reduced the hepatic fat accumulation by inhibiting the levels of triglyceride, total cholesterol and adipose hollow space in HFD-induced mice liver tissues. Additionally, KSO administration down-regulated the expression of inflammation-related cytokines (TNF-alpha, IL-1 beta and IL-6) and lipid synthesis related genes (PPAR-gamma and FAS), while upregulated the expression of fatty acid beta oxidation-related genes (PPAR-alpha, CPT1a and CPT1b) and thermogenesis-related gene (UCP2) in liver both in transcriptional and translational levels. Overall, our results implicate that KSO as a potential dietary supplement for the prevention of obesity.