Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2018.00432
Keywords
neurogenesis; astrocytes; Alzheimer's disease; neurogenic niche; secretion
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Funding
- Swiss National Science Foundation [31003A_173128]
- Synapsis Foundation
- Swiss National Science Foundation (SNF) [31003A_173128] Funding Source: Swiss National Science Foundation (SNF)
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Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there is a growing body of evidence showing that, in the hippocampus, this process contributes to mechanisms of memory as well as depression. Interestingly, adult neurogenesis is tightly regulated by the neurogenic niche, which provides a structural and molecular scaffold for stem cell proliferation and the differentiation and functional integration of new neurons. In this review, we highlight the role of astrocytes in the regulation of adult neurogenesis in the context of cognitive function. We also discuss how the changes in astrocytes function may dysregulate adult neurogenesis and contribute to cognitive impairment in the context of Alzheimer's disease.
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