Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2018.00469
Keywords
light-shaping; three-dimensional photostimulation; three-dimensional functional imaging; all-optical neuronal studies; optogenetics; neural circuits
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Funding
- Agence Nationale de la Recherche ANR [ANR-15-CE19-0001-01, 3DHoloPAc]
- European Research Council [610110]
- National Institutes of Health (NIH) [1UF1NS107574-01]
- Human Frontier Science Program (HFSP) [RGP0015/2016]
- Fondation Bettencourt Shueller (Prix Coups d'Elan pour la Recherche Francaise)
- AXA Research Fund
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Optical means for modulating and monitoring neuronal activity, have provided substantial insights to neurophysiology and toward our understanding of how the brain works. Optogenetic actuators, calcium or voltage imaging probes and other molecular tools, combined with advanced microscopies have allowed an all-optical readout and modulation of neural circuits. Completion of this remarkable work is evolving toward a three-dimensional (3D) manipulation of neural ensembles at a high spatiotemporal resolution. Recently, original optical methods have been proposed for both activating and monitoring neurons in a 3D space, mainly through optogenetic compounds. Here, we review these methods and anticipate possible combinations among them.
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