Journal
WORLD JOURNAL OF SURGERY
Volume 43, Issue 2, Pages 634-641Publisher
SPRINGER
DOI: 10.1007/s00268-018-4814-4
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Funding
- Japan Society for the Promotion of Science [24592018, 16K10588]
- Grants-in-Aid for Scientific Research [16K10588, 24592018] Funding Source: KAKEN
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BackgroundSurvival after surgery for pancreatic adenocarcinoma (PA) is poor and heterogeneous, even for curative (R0) resection. Serum carbohydrate antigen (CA) 19-9 levels are important prognostic markers for resected PA. However, sustained elevation of CA19-9 in association with the patterns of recurrence has been rarely investigated.MethodsPatients who underwent R0 resection (n=539) were grouped according to postoperative serum CA19-9 levels (Group E: sustained elevation; Group N: no elevation). Clinicopathological factors, patterns of recurrence, and survival were compared between the groups.ResultsGroup E (n=159) had significantly shorter median overall survival (17.1 vs. 35.4months, p<0.0001) than Group N (n=380). Postoperative CA19-9 elevation was a significant independent predictor of poor survival in multivariate analysis (hazard ratio 1.98, p<0.0001). The rate of hepatic recurrence in Group E was 2.6-fold higher than in Group N (45% vs. 17%, p<0.0001). Postoperative CA19-9 elevation was a strongest independent predictor of primary hepatic recurrence (p<0.0001) by a multiple regression model. Loco-regional, peritoneal, and other distant recurrence did not differ between the groups. The extent of preoperative CA19-9 elevation was correlated sustained elevation of CA19-9 after surgery (p<0.0001) and primary hepatic recurrence (p=0.0019).ConclusionsSustained CA19-9 elevation was strong predictor of primary hepatic recurrence and short survival in cases of R0 resection for PA.
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