Journal
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Volume 21, Issue 10, Pages 784-789Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2018.1563721
Keywords
Cocaine use disorders; crack; HTR2B gene; impulsivity; ADHD
Categories
Funding
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Fondation pour la Recherche sur le Cerveau
- Fondation pour la Recherche Medicale [Equipe FRM DEQ2014039529]
- French Ministry of Research (Agence Nationale pour la Recherche) [ANR-17-CE16-0008]
- French Ministry of Research (Investissements d'Avenir programme) [ANR-11-IDEX-0004-02]
- French state funds by the ANR within the Investissements d'Avenir programme [ANR-11-IDEX-0004-02]
- University Hospital of Martinique
- Clinical Research and Innovation Unit (DRCI) of the University Hospital of Martinique
- Sorbonne Universites
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Objectives: Cocaine dependence has a strong heritability component. The aim of this study was to investigate the putative association between the serotonin 2B receptor gene (HTR2B), crack use disorders and impulsivity. Methods: A French Afro-Caribbean male population of patients with crack use disorders (n = 80) was compared to healthy Afro-Caribbean male controls (n = 60). Comorbid ADHD and impulsivity were assessed. Five single nucleotide polymorphisms (SNPs) in the HTR2B gene were selected: rs643700, rs6736017, rs1549339, rs17586428 and rs3806545. These SNPs were chosen to include most of the linkage disequilibrium blocks in the HTR2B gene. The French translation of the Barratt Impulsivity Scale BIS-11 was used to evaluate impulsivity. Comorbid ADHD was diagnosed using the Wender Utah Rating Scale-25 item for Attention Deficit-Hyperactivity Disorder. Results: We have observed a positive association between the rs6736017 polymorphism and crack use disorders in a French Afro-Caribbean male population. Conclusions: In our population, the risk effect of HTR2B rs6736017 appeared to be specific to individuals with crack use disorders rather than being driven by impulsivity or ADHD alone.
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