Journal
VIRCHOWS ARCHIV
Volume 474, Issue 2, Pages 159-168Publisher
SPRINGER
DOI: 10.1007/s00428-018-2483-1
Keywords
Non-small cell lung cancer; Tumor-infiltrating lymphocytes; IDO-1; PD-L1; Immunotherapy
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Several cancers, especially non-small cell lung cancer (NSCLC), are able to escape the immunosurveillance of tumor-infiltrating lymphocytes (TILs); among the molecules involved, the indoleamine 2,3-dioxygenase 1 (IDO-1) and the programmed cell death ligand-1 (PD-L1) play a crucial role. These aspects are of great interest in the current immunotherapeutic era, therefore the current study analyses the TILs, IDO-1, and PD-L1 interactions and their correlations with clinicopathological parameters and prognosis in NSCLC. One hundred ninety-three NSCLC surgical specimens, formalin-fixed, and paraffin-embedded were assessed for TILs density, TILs localization, IDO-1 (clone 4.16H1), and PD-L1 (clone E1L3N) immunohistochemical expressions. This data was correlated with clinicopathological parameters, disease free, and overall survivals. IDO-1 and PD-L1 high expressions were related to the solid pattern of adenocarcinomas (respectively p=0.036 and p=0.026); high PD-L1 expression was correlated with squamous histotype (p=0.048). IDO-1 overexpression correlated with former smokers (p=0.041), higher adenocarcinoma stages (p=0.039), and with both higher TILs density and PD-L1 expression (respectively p=0.025 and p=0.0003). A better prognosis was associated with TILs intratumoral or mixed localizations (p=0.029). TILs localization affects NSCLC prognosis; the higher expression of IDO-1 and PD-L1 in poorly differentiated and more aggressive lung adenocarcinomas, as well as the correlation between high PD-L1 expression and squamous cell histotype, confirm the more efficient immunoescaping of these NSCLC subgroups.
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