Immunology of the canine eye in health and disease: a concise review

The canine eye is an immune-privileged organ that is provided with systems to prevent and control the local immune response, which could have a detrimental impact. The entry of blood-derived antigens is hindered by the blood-ocular barriers and potential invading pathogens are tackled by local antimicrobial molecules. Despite the existence of numerous immune-competent cells, the anterior chamber of the eye is characterised by low responsiveness. This review is focused on the innate and adaptive immunity employed to control health and disease in the canine eye.