Journal
TURKISH JOURNAL OF CHEMISTRY
Volume 42, Issue 5, Pages 1310-1320Publisher
Scientific and Technological Research Council Turkey
DOI: 10.3906/kim-1805-18
Keywords
DNA binding; absorption spectroscopy; gel electrophoresis; thermal melting; phthalocyanine compound
Funding
- Commission of Scientific Research Projects of Karabuk University
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In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide was synthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of the zinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorption spectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymus DNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study was also carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakis phenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative binding mode.
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