Journal
TUBERCULOSIS
Volume 114, Issue -, Pages 1-8Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2018.10.011
Keywords
Mycobacterium tuberculosis; B lymphocytes; B cell follicles; Lung; Antibodies; Cytokines
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Funding
- Russian Science Foundation [18-45-04015]
- Russian Science Foundation [18-45-04015] Funding Source: Russian Science Foundation
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The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.
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