Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 39, Issue 12, Pages 1004-1007Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2018.09.008
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Funding
- NIH [RO1 AG046153, RF1 AG054714, R41AI104034]
- California Institute of Regenerative Medicine (CIRM)
- Paul F. Glenn Center for Aging Research at the Salk Institute
- Edward N. & Della Thome Memorial Foundation
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Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.
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