Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 40, Issue 1, Pages 4-7Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2018.10.008
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The myeloid-derived suppressor cell (MDSC) is the 'queen bee' of the tumor microenvironment. MDSCs protect the cancer from the patient's immune system, make the tumor resistant to immunotherapy, and allow the tumor to thrive while the patient withers away. Eliminating MDSCs should improve response rates to cancer therapy and patient survival.
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