Journal
TRENDS IN MOLECULAR MEDICINE
Volume 25, Issue 2, Pages 70-72Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2018.12.001
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Funding
- European Commission (ITN EU-GliaPhD)
- European Commission (ERA-NET NEURON, BrIE)
- Bundesministerium fur Bildung und Forschung (CONNEXIN)
- Deutsche Forschungsgemein-schaft [SPP1757, STE 552/5-2]
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The etiology of temporal lobe epilepsy is unclear, but proinflammatory molecules and disturbed neuron-glia communications are emerging as potential causers. A recent study (Nikolic et al. Glia 2018; https://doi.org/10.1002/glia.23519) revealed that pathologically elevated tumor necrosis factor a contributes to epileptogenesis, by boosting hyperexcitation through an autocrine mechanism involving purinergic signaling, astrocyte glutamate release, and modulation of neuronal transmitter release.
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