Journal
TRENDS IN MICROBIOLOGY
Volume 27, Issue 3, Pages 268-281Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2018.11.004
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Funding
- European Union [665807]
- Institut Carnot Pasteur Microbes Sante
- Fondation pour la Recherche Medicale
- ANR ASTER [ANR-16-CE23-0001]
- LabEx IBEID [10-LABX-0062]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE23-0001] Funding Source: Agence Nationale de la Recherche (ANR)
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Alteration of host cell splicing is a common feature of many viral infections which is underappreciated because of the complexity and technical difficulty of studying alternative splicing (AS) regulation. Recent advances in RNA sequencing technologies revealed that up to several hundreds of host genes can show altered mRNA splicing upon viral infection. The observed changes in AS events can be either a direct consequence of viral manipulation of the host splicing machinery or result indirectly from the virus-induced innate immune response or cellular damage. Analysis at a higher resolution with single-cell RNAseq, and at a higher scale with the integration of multiple omics data sets in a systems biology perspective, will be needed to further comprehend this complex facet of virus-host interactions.
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