Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 2, Pages 81-83Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.12.005
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Aberrant expression of T cell-resident programmed cell death protein-1 (PD-1) is known to promote tumor progression. A recent study (Nature 2018; 564: 130-135) has now identified the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-1 protein turnover in T cells, providing a novel mechanism for potential use in cancer immunotherapy.
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