Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 1, Pages 22-34Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.11.001
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Funding
- European Research Council [789384] Funding Source: Medline
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Dendritic cells (DCs) are critical for the activation of naive CD4(+) T cells and are considered professional antigen-presenting cells (APCs), as are macrophages and B cells. Recently, several innate type 2 immune cells, such as basophils, mast cells (MCs), eosinophils, and innate type 2 lymphocytes (ILC2), have also emerged as harboring APC behavior. Through surface expression or transfer of peptide-loaded MHCII, expression of costimulatory and co-inhibitory molecules, as well as the secretion of polarizing cytokines, these innate cells can extensively communicate with effector and regulatory CD4(+) T cells. An exciting new concept is that the complementary tasks of these 'amateur' APCs contribute to shaping and regulating adaptive immunity to allergens and helminths, often in collaboration with professional APCs.
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