Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 1, Pages 66-80Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.11.006
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Funding
- Plan Nacional de I+ D+ I 2013-2016, Instituto de Salud Carlos III [PI16/01318, PI17/01244]
- European Union Fondos FEDER, Instituto de Salud Carlos III [PI16/01318, PI17/01244]
- Red Espanola de Investigacion Renal (REDinREN) [RD16/0009/0020]
- Ministry of Economy and Competitiveness through a Juan de la Cierva postdoctoral fellowship [FJCI-2015-24036]
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Infiltrating and tissue-resident myeloid cells are essential regulators of innate and adaptive immunity. During inflammation, and in response to microbial products, these cells can adapt to microenvironmental conditions and acquire specialized functions, including phagocytosis and the production of proinflammatory cytokines. Such myeloid plasticity is driven, in part, by epigenetic dynamics that can sustain stable phenotypes after activation, and which may lead to maladaptive cell polarization states associated with inflammation and autoimmunity. Here, we review recent reports describing epigenetic mechanisms linked to such polarization states and innate immune memory (tolerance and training) in monocyte and macrophage lineages. We discuss how these mechanisms might be targeted to develop putative immunomodulatory tools that might be used to treat a variety of immune-mediated diseases.
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