Journal
TRENDS IN CELL BIOLOGY
Volume 29, Issue 4, Pages 323-338Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.12.007
Keywords
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Categories
Funding
- MRC [NIRG-G1002186]
- NC3R [NC/L000199/1]
- Ataxia UK [A43]
- Alzheimer Research UK [PPG2017B-018]
- Motor Neurone Disease Association [855-791]
- ANR Ire1-PD [13-ISV4-0003]
- ARC foundation
- la Ligue contre le Cancer
- Rhone
- France Parkinson
- Fondation de France [2012-00034435]
- FINOVI grants [2017-01 26-A011]
- European Union FP7/AIRC -Associazione Italiana Ricerca sul Cancro Reintegration Grant (iCARE) [17885]
- University of Trieste FRA 2018 Starting Grant
- Flemish grants (Research Foundation Flanders) [FWO G.0C31.14N, FWO G0E04.16N, G.0C76.18N, G.0B71.18N]
- Flemish grants (Methusalem grants) [BOF16/MET_V/007]
- Foundation against Cancer [FAF-F/2016/865]
- VIB
- ANR LipidinRetina [12-BSV1-0019]
- [EOS 30826052 MODEL-IDI]
- MRC [G1002186] Funding Source: UKRI
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In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the spectrum of different forms of regulated cell death (RCD) has expanded dramatically with relevance in several pathologies such as inflammatory and neurodegenerative diseases. This has been paralleled by the growing awareness of the central importance of autophagy as a stress response that influences decisions of cell life and cell death. Here, we first introduce criteria and methodologies for correct identification of the different RCD forms. We then discuss how the autophagy machinery is directly associated with specific cell death forms and dissect the complex interactions between autophagy and apoptotic and necrotic cell death. This highlights how the balance of the relationship between other cell death pathways and autophagy presides over life and death in specific cellular contexts.
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