Journal
TRENDS IN CELL BIOLOGY
Volume 29, Issue 3, Pages 227-240Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.11.004
Keywords
-
Categories
Funding
- University of Queensland International Scholarship
- Stafford Fox Senior Research Fellowship
- NHMRC [1128381]
- National Health and Medical Research Council of Australia [1128381] Funding Source: NHMRC
Ask authors/readers for more resources
Mitochondrial genome (mitochondrial DNA, mtDNA) lesions that unbalance bioenergetic and oxidative outputs are an important cause of human disease. A major impediment in our understanding of the pathophysiology of mitochondrial disorders is the complexity with which mtDNA mutations are spatiotemporally distributed and managed within individual cells, tissues, and organs. Unlike the comparatively static nuclear genome, accumulating evidence highlights the variability, dynamism, and modifiability of the mtDNA nucleotide sequence between individual cells overtime. In this review, we summarize and discuss the impact of mtDNA defects on disease within the context of a mosaic and shifting mutational landscape.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available