4.4 Review

Lysosome: The metabolic signaling hub

Related references

Note: Only part of the references are listed.
Article Cell Biology

Regulation of metabolic health by essential dietary amino acids

Cara L. Green et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

Article Multidisciplinary Sciences

Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation

Holly M. Brown-Borg et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2018)

Review Biochemistry & Molecular Biology

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Sarah Pickles et al.

CURRENT BIOLOGY (2018)

Article Geriatrics & Gerontology

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

Tea Shavlakadze et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

Article Multidisciplinary Sciences

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

Kuang Shen et al.

NATURE (2018)

Review Oncology

Targeting the PI3K pathway in cancer: are we making headway?

Filip Janku et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Multidisciplinary Sciences

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

Gregory A. Wyant et al.

SCIENCE (2018)

Review Neurosciences

Association Between Autophagy and Neurodegenerative Diseases

Nobuhiro Fujikake et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Benjamin D. Hopkins et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

Ming-Yuan Su et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

SZT2 dictates GATOR control of mTORC1 signalling

Min Peng et al.

NATURE (2017)

Article Multidisciplinary Sciences

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Haijuan Yang et al.

NATURE (2017)

Article Multidisciplinary Sciences

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Rachel L. Wolfson et al.

NATURE (2017)

Article Multidisciplinary Sciences

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

David M. Sabatini

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

Mariana E. G. de Araujo et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

Xin Gu et al.

SCIENCE (2017)

Review Cell Biology

Recent progress in autophagic lysosome reformation

Yang Chen et al.

TRAFFIC (2017)

Article Multidisciplinary Sciences

Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1

Tianlong Zhang et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Ryo Yonehara et al.

NATURE COMMUNICATIONS (2017)

Article Geriatrics & Gerontology

RHEB1 insufficiency in aged male mice is associated with stress-induced seizures

Qi Tian et al.

GEROSCIENCE (2017)

Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

Article Multidisciplinary Sciences

METABOLISM Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Robert A. Saxton et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

METABOLISM Sestrin2 is a leucine sensor for the mTORC1 pathway

Rachel L. Wolfson et al.

SCIENCE (2016)

Review Cell Biology

The Lysosome as a Regulatory Hub

Rushika M. Perera et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)

Article Biochemistry & Molecular Biology

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Lynne Chantranupong et al.

Review Cell Biology

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

Brian K. Kennedy et al.

CELL METABOLISM (2016)

Article Cell Biology

Determinants of rodent longevity in the chaperone-protein degradation network

Karl A. Rodriguez et al.

CELL STRESS & CHAPERONES (2016)

Article Cell Biology

Kinesin 1 Drives Autolysosome Tubulation

Wanqing Du et al.

DEVELOPMENTAL CELL (2016)

Article Biochemistry & Molecular Biology

Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy

Jiqian Zhang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

Cindy Puente et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia

Mingming Zhong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Cell Biology

TFEB at a glance

Gennaro Napolitano et al.

JOURNAL OF CELL SCIENCE (2016)

Article Geriatrics & Gerontology

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

Sebastian I. Arriola Apelo et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

Review Geriatrics & Gerontology

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Sebastian I. Arriola Apelo et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

Editorial Material Biochemistry & Molecular Biology

mTORC2 Puts Its Shoulder to Krebs' Wheel

Sebastian I. Arriola Apelo et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

Robert A. Saxton et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

The apo-structure of the leucine sensor Sestrin2 is still elusive

Robert A. Saxton et al.

SCIENCE SIGNALING (2016)

Article Multidisciplinary Sciences

Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

Eleftherios Karanasios et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

The apo-structure of the leucine sensor Sestrin2 is still elusive

Robert A. Saxton et al.

SCIENCE SIGNALING (2016)

Article Multidisciplinary Sciences

FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1

Xiaochun Wu et al.

PLOS ONE (2016)

Review Biochemistry & Molecular Biology

Nutrient-Sensing Mechanisms across Evolution

Lynne Chantranupong et al.

Article Medicine, Research & Experimental

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

Shihyin Tsai et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Medicine, Research & Experimental

The role for autophagy in cancer

Eileen White

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

Jennifer Jung et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

David G. McEwan et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

Esperanza Arias et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Daniel F. Egan et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

Jiajie Diao et al.

NATURE (2015)

Article Multidisciplinary Sciences

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Manuele Rebsamen et al.

NATURE (2015)

Article Cell Biology

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

Diego L. Medina et al.

NATURE CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Shuyu Wang et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Hanseong Kim et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Pengda Liu et al.

CANCER DISCOVERY (2015)

Article Cell Biology

mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1

Sebastiano Sciarretta et al.

CELL REPORTS (2015)

Article Biochemistry & Molecular Biology

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

Constantinos Demetriades et al.

Review Cell Biology

Chaperone-mediated autophagy: roles in disease and aging

Ana Maria Cuervo et al.

CELL RESEARCH (2014)

Article Cell Biology

Autophagy and human disease: emerging themes

Jaime L. Schneider et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2014)

Article Cell Biology

RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

Alejo Efeyan et al.

DEVELOPMENTAL CELL (2014)

Article Biochemistry & Molecular Biology

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

Dudley W. Lamming et al.

FASEB JOURNAL (2014)

Article Cell Biology

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17

Peidu Jiang et al.

MOLECULAR BIOLOGY OF THE CELL (2014)

Article Medicine, General & Internal

Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer

Nikhil Wagle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Cell Biology

mTOR inhibition improves immune function in the elderly

Joan B. Mannick et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Cell Biology

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

Anita Parmigiani et al.

CELL REPORTS (2014)

Review Multidisciplinary Sciences

Diminished mTOR signaling: a common mode of action for endocrine longevity factors

Dudley W. Lamming

SPRINGERPLUS (2014)

Review Biochemistry & Molecular Biology

Endocytosis and autophagy: Shared machinery for degradation

Christopher A. Lamb et al.

BIOESSAYS (2013)

Review Cell Biology

A Central Role for mTOR in Lipid Homeostasis

Dudley W. Lamming et al.

CELL METABOLISM (2013)

Article Biochemistry & Molecular Biology

The lipid kinase PI4KIIIβ preserves lysosomal identity

Sunandini Sridhar et al.

EMBO JOURNAL (2013)

Article Cell Biology

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

Constance S. Petit et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice

Sasmita Tripathy et al.

JOURNAL OF LIPID RESEARCH (2013)

Article Biochemistry & Molecular Biology

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

Zhi-Yang Tsun et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy

Santosh Chauhan et al.

MOLECULAR CELL (2013)

Article Cell Biology

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Ryan C. Russell et al.

NATURE CELL BIOLOGY (2013)

Review Cell Biology

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

Carmine Settembre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals

Samarpita Sengupta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

Charles Betz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Issam Ben-Sahra et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

Seong A. Kang et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

Nicolas Panchaud et al.

SCIENCE SIGNALING (2013)

Article Multidisciplinary Sciences

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Jong-Ok Pyo et al.

NATURE COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1

Liron Bar-Peled et al.

Article Biochemistry & Molecular Biology

A complex immunodeficiency is based on U1 snRNP-mediated poly(A) site suppression

Joerg Langemeier et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre et al.

EMBO JOURNAL (2012)

Review Oncology

The cellular pathology of lysosomal diseases

Timothy M. Cox et al.

JOURNAL OF PATHOLOGY (2012)

Article Biochemistry & Molecular Biology

Glutaminolysis Activates Rag-mTORC1 Signaling

Raul V. Duran et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Christian C. Dibble et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Agnes Roczniak-Ferguson et al.

SCIENCE SIGNALING (2012)

Review Cell Biology

Protein homeostasis and aging: The importance of exquisite quality control

Hiroshi Koga et al.

AGEING RESEARCH REVIEWS (2011)

Article Biochemistry & Molecular Biology

Activation of mTORC2 by Association with the Ribosome

Vittoria Zinzalla et al.

Article Biochemistry & Molecular Biology

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

Michela Palmieri et al.

HUMAN MOLECULAR GENETICS (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Article Multidisciplinary Sciences

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre et al.

SCIENCE (2011)

Article Multidisciplinary Sciences

The metabolic footprint of aging in mice

Riekelt H. Houtkooper et al.

SCIENTIFIC REPORTS (2011)

Article Biochemistry & Molecular Biology

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

Dale W. Hailey et al.

Article Biochemistry & Molecular Biology

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

Mirjana Nordmann et al.

CURRENT BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Structural Conservation of Components in the Amino Acid Sensing Branch of the TOR Pathway in Yeast and Mammals

Konstantin Kogan et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

Termination of autophagy and reformation of lysosomes regulated by mTOR

Li Yu et al.

NATURE (2010)

Article Multidisciplinary Sciences

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Shomit Sengupta et al.

NATURE (2010)

Article Cell Biology

Plasma membrane contributes to the formation of pre-autophagosomal structures

Brinda Ravikumar et al.

NATURE CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

David E. Harrison et al.

NATURE (2009)

Article Multidisciplinary Sciences

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Colin Selman et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chong Chen et al.

SCIENCE SIGNALING (2009)

Article Biochemistry & Molecular Biology

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

Tsuneo Ikenoue et al.

EMBO JOURNAL (2008)

Article Biochemistry & Molecular Biology

The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

Urmi Bandyopadhyay et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

Jin-Na Min et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Cell Biology

Regulation of TORC1 by Rag GTPases in nutrient response

Eunjung Kim et al.

NATURE CELL BIOLOGY (2008)

Article Genetics & Heredity

A role for autophagy in the extension of lifespan by dietary restriction in C-elegans

Malene Hansen et al.

PLOS GENETICS (2008)

Article Multidisciplinary Sciences

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Yasemin Sancak et al.

SCIENCE (2008)

Review Cell Biology

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

Michoel Forgac

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

Dung-Fang Lee et al.

Article Biochemistry & Molecular Biology

Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1

Changhua Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14

Georg Bohn et al.

NATURE MEDICINE (2007)

Article Biochemistry & Molecular Biology

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

Maria A. Frias et al.

CURRENT BIOLOGY (2006)

Article Cell Biology

The lysosome turns fifty

C de Duve

NATURE CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

The TOR and EGO protein complexes orchestrate microautophagy in yeast

F Dubouloz et al.

MOLECULAR CELL (2005)

Article Multidisciplinary Sciences

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

DD Sarbassov et al.

SCIENCE (2005)

Article Cell Biology

Role for Rab7 in maturation of late autophagic vacuoles

S Jäger et al.

JOURNAL OF CELL SCIENCE (2004)

Review Multidisciplinary Sciences

Linking albinism and immunity: The secrets of secretory lysosomes

J Stinchcombe et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

TSC2 mediates cellular energy response to control cell growth and survival

K Inoki et al.

Article Cell Biology

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Y Zhang et al.

NATURE CELL BIOLOGY (2003)

Article Cell Biology

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

K Inoki et al.

NATURE CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

K Hara et al.

Article Biochemistry & Molecular Biology

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

T Sekiguchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)