Journal
TOXICON
Volume 156, Issue -, Pages 48-51Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2018.11.006
Keywords
Tetrodotoxin; TTX; Tetrodotoxin analogues; Nemerteans; HPLC-MS/MS
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Funding
- Russian Foundation for Basic Research (RFBR) [18-04-00808 A.]
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For the first time search for tetrodotoxin (TTX) and its analogues in the extracts of nemerteans using HPLC-MS/MS was performed. TTX analogues were detected in two nemertean species in addition to TTX: 7 analogues were detected in the extract of Cephalothrix simula, 3 analogues-in the extract 11-norTTX of Kulikovia manchenkoi. Presence of 5-deoxyTTX, 11-deoxyTTX, 5,6,11-trideoxyTTX and -6(R)-ol in nemerteans was shown for the first time.
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