Journal
TISSUE ENGINEERING PART A
Volume 25, Issue 1-2, Pages 9-11Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.tea.2018.0315
Keywords
DNA; RNA delivery; RNA interference; microRNA; small interfering RNA; messenger RNA; mesenchymal stem cells; enabling technologies in tissue engineering
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RNA has several theoretical advantages as a therapeutic agent, but exploiting RNA in this fashion has faced several major hurdles. Not only is it unstable and difficult to deliver across hydrophobic cell membranes, but extraneous RNA also activates innate immune nucleic acid sensors, which makes it toxic and inflammatory.
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