Journal
TETRAHEDRON LETTERS
Volume 60, Issue 5, Pages 402-406Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.12.037
Keywords
5-Substituted-1H-tetrazoles; Aldehydes; One-pot synthesis; Deep eutectic solvent; Green chemistry
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Funding
- National Natural Science Foundation of China [21004024]
- Natural Science Foundation of Fujian Province [2016J01063]
- Program for New Century Excellent Talents in University of Fujian Province [2012FJ-NCET-ZR03]
- Promotion Program for Young and Middle-aged Teacher in Science and Technology Research of Huaqiao University [ZQN-YX103]
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A series of 5-substituted-1H-tetrazoles have been efficiently synthesized in moderate to excellent yields (68-90%) under mild reaction conditions by combining aryl aldehydes, hydroxylamine hydrochloride with sodium azide in the presence of catalytic amount of Cu(OAc)(2) in deep eutectic solvent (DES). The new synthetic method has many advantages, such as high conversion, green reaction medium, easy work-up, low cost, and environment friendly. (C) 2018 Elsevier Ltd. All rights reserved.
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