Journal
TETRAHEDRON LETTERS
Volume 59, Issue 52, Pages 4540-4544Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.11.009
Keywords
Fluorescence sensor; Viscosity; Ratiometric; Two photon
Categories
Funding
- Special Fund for Agroscientific Research in the Public Interest [201503108]
- National Natural Science Foundation of China [51678163, U1701243]
- Guangdong Provincial Science and Technology Project [2014A030308019, 2016B070701017, 2015A020215016]
- Special Foundation for the Science and Technology Innovation Leaders of Guangdong Province [2014TX01Z038]
- GDAS' Special Project of Science and Technology Development [2017GDASCX-0824, 2017GDASCX-0401]
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A new ratiometric two-photon fluorescence sensor, Qca-Cy2, comprised of a hybrid cyanine-carbazole platform with two rotating sites is described. Qca-Cy2 can report on mitochondrial viscosity within live cells, as well as in living tissues at depths of 50-130 mu m by ratiometric fluorescence imaging using two-photon microscopy. (C) 2018 Elsevier Ltd. All rights reserved.
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