Journal
TALANTA
Volume 192, Issue -, Pages 52-60Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2018.09.015
Keywords
Quinolones; Third-order multivariate analysis; Excitation-emission fluorescence matrices; pH-gradient; Glucono delta-lactone; U-PLS/RTL
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Funding
- Universidad Nacional de Rosario (UNR)
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 2016-11222016-1122]
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This paper describes a novel procedure for the simultaneous determination of four quinolones pipemidic acid, enoxacin, marbofloxacin and enrofloxacin in different edible animal tissues. It is based on third-order data excitation-emission fluorescence matrices modulated by pH gradient, generated in situ through the hydrolysis of glucono delta-lactone. To overcome the strongly overlapped spectra within the analytes, and also with the highly complex tissue matrix, we have used the multivariate calibration procedure unfolded partial least-squares coupled to residual trilinearization (U-PLS/RTL). The method has been validated by application to bovine kidney, chicken and porcine meat samples, fortified at concentration levels between 70 and 600 mu g kg(-1) corresponding to values near the maximum residue level (MRL) regulated by the European Community. Good recoveries were obtained for all analytes, with values between 80% and 113%, depending on the quinolone and the matrix.
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