Unsymmetrical Difunctionalization of Two Different C-H Bonds in One Pot Under Transition-Metal Catalysis

Recent advancements in unsymmetrical difunctionalization based on the substitution of two different C-H bonds in one-pot are described. Due to the difficulty of controlling reactivity and selectivity, multi-functionalization via substitution of several C-H bonds to install different functional groups has been limited until recently, in comparison with well-studied functionalization via sequential addition to unsaturated pi-bonds. This difunctionalization protocol provides an efficient and rapid approach to a library of structurally complicated target molecules through the formation of multiple C-X bonds with high atom-and step-economy.