Journal
SYNTHESIS-STUTTGART
Volume 51, Issue 1, Pages 40-54Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611066
Keywords
difunctionalization; C-H activation; regioselectivity
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Funding
- MEXT, Japan [16K05778]
- Grants-in-Aid for Scientific Research [16K05778] Funding Source: KAKEN
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Recent advancements in unsymmetrical difunctionalization based on the substitution of two different C-H bonds in one-pot are described. Due to the difficulty of controlling reactivity and selectivity, multi-functionalization via substitution of several C-H bonds to install different functional groups has been limited until recently, in comparison with well-studied functionalization via sequential addition to unsaturated pi-bonds. This difunctionalization protocol provides an efficient and rapid approach to a library of structurally complicated target molecules through the formation of multiple C-X bonds with high atom-and step-economy.
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