Journal
SURGERY TODAY
Volume 49, Issue 6, Pages 460-466Publisher
SPRINGER
DOI: 10.1007/s00595-018-1737-5
Keywords
Neoadjuvant therapy; Imatinib; Gastrointestinal stromal tumor; Rectum
Categories
Funding
- Japan Society for the promotion of Science [16K07143, 16K07161, 17K10620, 17K10621, 17K10623, 18K07194]
- Project for Cancer Research and Therapeutic Evolution P-CREATE from the Japan Agency for Medical Research and Development (AMED) [18cm0106502h0003]
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Rectal gastrointestinal stromal tumor (GIST) is a rare entity. Thus, its clinical features have not been well documented, and optimal treatment strategies have not been established. Surgery for rectal GISTs may be difficult because they are often large in size. In addition, rectal GISTs were found to be associated with high rates of local recurrence, regardless of the surgical procedure, before imatinib was introduced in the early 2000s. Since the introduction of imatinib therapy, accumulating evidence suggests that neoadjuvant imatinib therapy may improve the outcomes of rectal GIST treatment. Neoadjuvant imatinib therapy for rectal GISTs offers a number of potential benefits, including tumor downsizing, reduction in mitotic activity, reduced morbidity, and a reduced risk of recurrence. Less radical procedures may allow for the preservation of the anal sphincter and avoidance of a permanent colostomy. This review summarizes the current status and future perspectives of neoadjuvant imatinib therapy for the treatment of rectal GISTs.
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