Journal
SUPPORTIVE CARE IN CANCER
Volume 27, Issue 3, Pages 793-803Publisher
SPRINGER
DOI: 10.1007/s00520-018-4594-2
Keywords
Chemotherapy-induced nausea and vomiting; Stem cell transplantation; High-dose melphalan; Aprepitant; Quality of life
Ask authors/readers for more resources
IntroductionHigh-dose melphalan (HDMel) is the most common conditioning chemotherapy regimen for autologous stem cell transplantation (SCT) in patients affected by multiple myeloma (MM). No consensus exists for the emetogenicity or prophylaxis of chemotherapy-induced nausea and vomiting (CINV) in this regimen.MethodsData on the incidence and efficacy/safety of CINV prophylaxis among patients affected by MM undergoing autologous SCT with the HDMel regimen was extracted from electronic databases and analyzed.ResultsEleven studies involving multiple CINV prophylaxis regimens were identified and included. No consensus on HDMel emetogenicity was reached, but most studies summarized the emetogenicity as moderate-high risk. An aprepitant-based three-drug regimen (aprepitant+serotonin receptor antagonist (5HT3RA)+dexamethasone) showed better efficacy than a two-drug regimen (5HT3RA+dexamethasone) for CINV prevention without increasing the frequency in adverse events.ConclusionsThe aprepitant-based three-drug regimen should be the regimen of choice for CINV prophylaxis for MM patients undergoing autologous SCT with HDMel conditioning.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available