Journal
STEROIDS
Volume 141, Issue -, Pages 76-80Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2018.11.015
Keywords
Soft coral; Lobophytum sp.; Polyhydroxylated steroids; Lobophysterols A-D; Cytotoxicity
Funding
- National Key Research and Development Program of China [2018YFC0310903]
- National Natural Science Foundation of China [81520108028, 21672230, 41876194, 41506187, 81603022]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- SKLDR/SIMM Projects [SIMM 1705ZZ-01]
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Four new polyhydroxylated steroids lobophysterols A-D (1-4), together with two known related compounds sarcophytosterol (5) and klyflaccisteroid B (6), were isolated from the South China Sea soft coral Lobophytum sp. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. In bioassay, compound 4 showed weak cytotoxicities against HT-29, SNU-398, and Capan-1 cells.
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