Journal
SMALL
Volume 14, Issue 44, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201803256
Keywords
biomimetics; biomineralization; glucose oxidase-like activity; nanozymes; tandem catalysis
Categories
Funding
- National Natural Science Foundation of China [21705087, 21575074, 21775082]
- Special Foundation for Distinguished Taishan Scholar of Shandong Province [ts201511052]
- Major Basic Research Program of Natural Science Foundation of Shandong Province [ZR2018ZC0127]
- Project of Shandong Province Higher Educational Science and Technology Program [J18KA067]
- Research Foundation for Distinguished Scholars of Qingdao Agricultural University [663-1117015]
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It has been widely reported that naked gold nanoparticles (Au NPs) without protectors have glucose oxidase (GOx)-like activity, and the use of protectors can inhibit the GOx-like activity. Here, non-naked Au NPs with GOx-like activity are synthesized by using protein as protector. Although naked Au NPs have peroxidase-like activity and GOx-like activity, the optimal pH ranges of the both activities are obviously different. Fortunately, as-synthesized non-naked Au NPs show the dual enzyme-like activities at the same pH. So, non-naked Au NPs can be described as tandem nanozyme. As another bonus, the participation of protein protector can stabilize the GOx-like activity and make Au NPs modifiable. Even though Au NPs are connected with graphene oxide (GO), the GOx-like activity is still not changed. Further, Au NPs-GO nanocomposites are applied on the one-pot nonenzymatic glucose colorimetric detection. The non-naked gold not only broadens the species of tandem nanozymes, but also facilitates the functionalization of nanozymes, which is promising for immunoassay, biosensor, and medical treatment.
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